| 中文名 | 盐酸奥替尼啶 |
| 英文名 | N,N'-(decane-1,10-diyldi-1(4H)-pyridyl-4-ylidene)bis(octylammonium) dichloride |
| 别名 | 奥替尼啶杂质 盐酸奥替尼啶 奥替尼啶盐酸盐 奥克太啶盐酸盐 奥替尼定盐酸盐 奥替尼啶,奥克太啶 奥替尼啶 二盐酸盐 奥替尼啶 奥克太啶(双盐酸盐) |
| 英文别名 | Octenidine HCl Octenidine hydrochloride ocenidine dihydrochloride OCTENIDINE DIHYDROCHLORIDE N'-(decane-1,10-diyldi-1(4H)-pyridyl-4-ylidene)bis(octylaMMoniuM) dichloride N,N'-(decane-1,10-diyldipyridin-1-yl-4-ylidene)dioctan-1-amine dihydrochloride N,N'-(decane-1,10-diyldi-1(4H)-pyridyl-4-ylidene)bis(octylammonium) dichloride N,N'-(1,10-Decanediyldi-1(4H)-pyridinyl-4-ylidene)bis-1-octanaMine Hydrochloride N,N'-(1,10-Decanediyldi-1(4H)-pyridinyl-4-ylidene)bis(1-octanamine) dihydrochloride |
| CAS | |
| EINECS | |
| 化学式 | C36H64Cl2N4 |
| 分子量 | 623.82616 |
| InChI | InChI=1/C36H62N4.2ClH/c9-27-37-35-23-31-39(32-24-35)29-2-33-25-36(26-34-40)38-28-20-;;/h23-26,31-34H,3-22,27-30H2,1-2H3;2*1H |
| InChIKey | SMGTYJPMKXN |
| 密度 | 1.046[at 20℃] |
| 熔点 | 215-217℃ |
| 沸点 | 609.3°C at 760 mmHg |
| 闪点 | 322.3°C |
| 水溶性 | 14.2g/L at 20℃ |
| 蒸汽压 | 0Pa at 25℃ |
| 溶解度 | Soluble in dimethyl sulfoxide and methanol. |
| 存储条件 | Keep in dark place,Inert atmosphere,Room temperature |
| 稳定性 | Hygroscopic |
| 外观 | Solid |
| 颜色 | White to Off-White |
| Merck | 14,6754 |
| 体外研究 | Octenidine concentrations of less than1.5 μM (0.94 μg/mL) causes a greater than 99% reduction of tested microbial population within 15 min. Staphylococcus epidermidis is the most susceptible of the test organisms, and E. coli and C. albicans are the least susceptible. |
| 体内研究 | The antimicrobial activity of octenidine hydrochloride (OCT) is maintained when applied to the skin of the hands and feet of cynomolgus monkeys. Aqueous octenidine, at a concentration of 0.2 to 1.6% reduces resident microflora populations from 90 to 99.98%. A significant reduction in plaque score is observed on the buccal tooth surfaces after daily topical application of 1% solutions of octenidine and chlorhexidine for 7 d; octenidine is more effective than chlorhexidine. |